Medication Overuse Headaches Last week we addressed the Top 10 Migraine Triggers. Number 10 on that list is medication overuse headaches (“MOH”). Medication overuse headaches are caused by overuse of medications, including both prescription and over the counter medications (most commonly, Advil, Aleve, Excedrin, Triptans, Caffeine, Codeine, Oxycodone, and other similar medications).